Vaccine

Prevention of Lyme Disease Through Active Immunization:

Recommendations of the Advisory Committee on Immunization Practices (ACIP)

Prevention and Control of Lyme Disease

Avoidance of Tick Habitat
Whenever possible, persons should avoid entering areas that are likely to be infested with ticks, particularly in spring and summer when nymphal ticks feed. Ticks favor a moist, shaded environment, especially that provided by leaf litter and low-lying vegetation in wooded, brushy or overgrown grassy habitat. Both deer and rodent hosts must be abundant to maintain the enzootic cycle of B. burgdorferi.. Sources for information on the distribution of ticks in an area include state and local health departments, park personnel, and agricultural extension services.

Personal Protection
Individuals who are exposed to tick infested areas should wear light-colored clothing so that ticks can be spotted more easily and removed before becoming attached. Wearing long sleeved shirts and tucking pants into socks or boot tops may help keep ticks from reaching the skin. Ticks are usually located close to the ground, so wearing high rubber boots may provide additional protection. Application of insect repellents containing DEET (n,n-diethyl-m-toluamide) to clothes and exposed skin, and permethrin (which kills ticks on contact) to clothes, should also help reduce the risk of tick attachment. DEET can be used safely on children and adults but should be applied according to Environmental Protection Agency guidelines to reduce the possibility of toxicity (58).

Tick Check and Removal
Since transmission of B. burgdorferi from an infected tick is unlikely to occur before 36 hours of tick attachment (27, 59), daily checks for ticks and their prompt removal will help prevent infection.

Prophylaxis after Tick Bite
The relative cost-effectiveness of post-exposure treatment of tick bites to avoid Lyme disease in endemic areas is dependent on the probability of B. burgdorferi infection after a tick bite (60). In most circumstances, treating persons with tick bite alone is not recommended (6, 61). Individuals who are bitten by a deer tick should remove the tick and seek medical attention if any signs or symptoms of early Lyme disease, ehrlichiosis, or babesiosis develop over the ensuing weeks.

Strategies to Reduce Tick Abundance
The number of ticks in endemic residential areas may be reduced by removing leaf litter, brush- and wood-piles around houses and at the edges of yards, and by clearing trees and brush to admit more sunlight and reduce the amount of suitable habitats for deer, rodents, and ticks (62). Tick populations have also been effectively suppressed through the application of pesticides to residential properties (63, 64). Community based interventions to reduce deer populations or to kill ticks on deer and rodents have not been extensively implemented, but may be effective in reducing community wide risk of Lyme disease (65). The effectiveness of deer feeding stations equipped with pesticide applicators to kill ticks on deer, and other baited devices to kill ticks on rodents, is currently under evaluation.

Early Diagnosis and Treatment
Lyme disease in its early stages is a readily treatable disease (5, 6). The early diagnosis and proper antibiotic treatment of Lyme disease is an important strategy to avoid morbidity and costs of complicated and late-stage illness.

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